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质谱表征

质谱表征卓越中心(Mass Spectrometry Center of Excellent)为复杂的工艺研发和产品生产、调查等提供质谱技术支持,如蛋白质质谱结构表征分析,蛋白质精细表征分析,蛋白质糖谱表征分析,宿主蛋白质质谱分析。中心拥有8台一流的质谱设备,30+质谱分析专家,已完成100+各类型分子的质谱表征,包括mAb, Bi-specific, Fusion protein等。

 

中心为客户提供完整的质谱表征策略, 

并积极承接独立的质谱分析业务:


  • Sequence coverage by LC-MS/MS
  • N- and C-terminal sequence by LC-MS/MS
  • Post-translational Modification by LC-MS/MS
  • Disulfide linkage analysis by LC-MS
  • Intact/deglycosylated intact mass analysis by LC-MS
  • Reduced/deglycosylated reduced mass analysis by LC-MS
  • Middle level Ides digestion mass analysis by LC-MS
  • CE-MS with 908 Device
  • Quick N-Glycan analysis by LC-MS
  • N-glycosylation ID and analysis by FLD and HILIC-MS
  • N and O-glycosylation ID and analysis by glycopeptides using LC-MS/MS
  • N- or O-glycosylation sites by LC-MS/MS
  • Qualitative ID HCP proteins by LC-MS/MS
  • Quantitative measurement of HCP proteins by LC-MS/MS
  • Sequence variants analysis by LC-MS/MS
  • Impurity characterization (peak fractionation and characterization)
  • MSn technique to identify mutation and rare PTMs

主要设备

主要设备